Lindskov R, Hølmer G
Department of Dermatology, Finsen Institute, Copenhagen, Denmark.
Allergy. 1992 Oct;47(5):517-21. doi: 10.1111/j.1398-9995.1992.tb00675.x.
Recent studies of polyunsaturated fatty acids (PUFA) in plasma and blood cell components of patients with atopic diseases have indicated disordered fat metabolism as linoleic acid (18:2n-6) tends to be increased while the more unsaturated fatty acids, such as gamma-linolenic acid (18:3n-6) and arachidonic acid (20:4n-6) are present in decreased amounts. To further clarify these abnormalities, we examined the PUFA content in phospholipids derived from plasma, red blood cells and mononuclear cells (MNC) in patients with atopic dermatitis. In plasma no significant differences were found between patients and controls. In red blood cells dihomo-gamma-linolenic acid (20:3n-6) was reduced in eczema patients, as compared with controls. The most significant findings in eczema patient MNC were reduced ratios of 20:4n-6/20:3n-6 in total lipids and in phosphatidyl ethanolamine (PE) and of 20:4n-6/18:2n-6 in both total lipids, phosphatidyl choline (PC) and PE. These findings indicate a disordered fatty acid metabolism in MNC of patients with atopic dermatitis. It is possible that these changes in the fatty acid profile of MNC may account for some of the immunological abnormalities seen in these patients.
近期针对特应性疾病患者血浆和血细胞成分中多不饱和脂肪酸（PUFA）的研究表明，脂肪代谢紊乱，因为亚油酸（18:2n - 6）往往会增加，而γ-亚麻酸（18:3n - 6）和花生四烯酸（20:4n - 6）等更不饱和的脂肪酸含量则会降低。为了进一步阐明这些异常情况，我们检测了特应性皮炎患者血浆、红细胞和单核细胞（MNC）中磷脂的PUFA含量。在血浆中，患者与对照组之间未发现显著差异。与对照组相比，湿疹患者红细胞中的二高 - γ-亚麻酸（20:3n - 6）减少。湿疹患者MNC中最显著的发现是，总脂质和磷脂酰乙醇胺（PE）中20:4n - 6/20:3n - 6的比值以及总脂质、磷脂酰胆碱（PC）和PE中20:4n - 6/18:2n - 6的比值均降低。这些发现表明特应性皮炎患者的MNC存在脂肪酸代谢紊乱。MNC脂肪酸谱的这些变化可能是这些患者出现某些免疫异常的部分原因。
