Ponkratov P A
Anesteziol Reanimatol. 1992 Jul-Aug(4):51-5.
The studies have been performed in 178 patients during and after surgery on the biliary ducts. The patients developed marked hyper-reaction of the sympathoadrenal system, total and regional hemodynamic disturbances, hypoxia, disorders in redox processes and blood viscosity and hypercoagulation. To prevent and eliminate the disorders observed small doses of ganglioblockers, alpha- and beta-blockers in combination with heparin were used during surgery and in the earliest postoperative period. As a result hyper-reaction of the sympathoadrenal system was considerably reduced, total and regional hemodynamic parameters were improved, hypoxia was attenuated, redox processes were activated, hypercoagulation decreased and blood viscosity was improved. Lethality in this group decreased from 7.9% to 1.1%. The above technique of neurovegetative adrenergic inhibition and heparinization enhanced adaptation capacities of the body to surgical intervention and improved the results of surgical treatment of patients with acute cholecystitis.
这些研究是在178例胆管手术期间及术后的患者中进行的。患者出现了交感肾上腺系统的明显高反应性、全身和局部血流动力学紊乱、缺氧、氧化还原过程和血液粘度及高凝状态的紊乱。为预防和消除所观察到的紊乱，在手术期间及术后早期使用了小剂量神经节阻滞剂、α和β阻滞剂与肝素联合应用。结果，交感肾上腺系统的高反应性显著降低，全身和局部血流动力学参数得到改善，缺氧减轻，氧化还原过程被激活，高凝状态降低，血液粘度得到改善。该组的死亡率从7.9%降至1.1%。上述神经植物性肾上腺素能抑制和肝素化技术增强了机体对手术干预的适应能力，并改善了急性胆囊炎患者的手术治疗效果。
