Lane M A, Ingram D K, Cutler R G, Knapka J J, Barnard D E, Roth G S
Molecular Physiology and Genetics Section, National Institute on Aging, National Institutes of Health, Francis Scott Key Medical Center, Baltimore, Maryland 21224.
Ann N Y Acad Sci. 1992 Dec 26;673:36-45. doi: 10.1111/j.1749-6632.1992.tb27434.x.
Rhesus and squirrel monkeys have been fed a semisynthetic diet at approximately ad libitum or 30% reduced levels for 3.5 (rhesus group 2) to 4.5 (rhesus group 1 and squirrel) years. Animals have maintained excellent health status as determined by physical examinations, hematology, and blood chemistry. While relative rates of body weight gain in restricted group 1 rhesus and squirrel monkeys have been markedly reduced, DR effects on crown-rump length (body height) have been variable. In addition, numerous physiological and biochemical parameters have been measured, and several exhibit significant cross-sectional age effects. Interestingly, several of these also exhibit possible species and genotype (group 1 and 2 rhesus) differences. A number of physiological parameters are emerging that might be altered by DR; however, further explanation of these effects awaits more extensive and detailed analyses.
恒河猴和松鼠猴被喂食半合成饲料，摄入量约为随意摄入量或减少30%，持续3.5年（恒河猴第2组）至4.5年（恒河猴第1组和松鼠猴）。通过体格检查、血液学和血液化学检查确定，这些动物的健康状况良好。虽然限制饮食的恒河猴第1组和松鼠猴的体重相对增加率明显降低，但饮食限制对顶臀长度（身体高度）的影响却各不相同。此外，还测量了许多生理和生化参数，其中一些表现出显著的横断面年龄效应。有趣的是，其中一些参数也表现出可能的物种和基因型（恒河猴第1组和第2组）差异。一些生理参数正在显现，可能会受到饮食限制的影响；然而，对这些影响的进一步解释还有待更广泛和详细的分析。
