Braun J J, Haas F, Conraux C
Service ORL, Hôpital de Hautepierre, Strasbourg.
Ann Otolaryngol Chir Cervicofac. 1992;109(4):189-99.
The authors report a series of 350 patients referred for clinical investigation of nasal polyps between 1980 and 1990. 93 patients were followed for more than 5 years. Allergy to inhalants was rarely found (2.8%). Detailed study of past rhinosinusal and bronchial symptoms often revealed a history of vasomotor rhinitis (nasal hyperreactivity HRN) preceding the nasal polyposis by a mean interval of 8 years. The ratio non-allergic vasomotor rhinitis/nasal polyps was 4.31 in women (41.4% of the patients) and 1.74 in men (58.6% of the patients). Treatment is usually based on the use of local corticosteroids. However, because of the variable clinical pattern of nasal polyposis treatment may be medical alone or both medical and surgical, and always requires a long clinical follow-up. Intolerance to aspirin is a factor of poor prognosis. A 15% failure rate was noted among patients intolerant to aspirin.
作者报告了1980年至1990年间因鼻息肉接受临床检查的350例患者。93例患者随访时间超过5年。吸入性过敏很少见（2.8%）。对既往鼻-鼻窦炎和支气管症状的详细研究常常发现，血管运动性鼻炎（鼻高反应性HRN）病史先于鼻息肉病，平均间隔8年。女性非过敏性血管运动性鼻炎/鼻息肉的比例为4.31（占患者的41.4%），男性为1.74（占患者的58.6%）。治疗通常基于局部使用皮质类固醇。然而，由于鼻息肉病的临床模式多变，治疗可能仅采用药物治疗，也可能采用药物和手术联合治疗，并且始终需要长期的临床随访。阿司匹林不耐受是预后不良的一个因素。阿司匹林不耐受的患者中有15%的失败率。
