Jäntti-Alanko S, Holopainen E, Malmberg H
Dept. of O.R.L., Helsinki University Central Hospital, Finland.
Rhinol Suppl. 1989;8:59-64.
Recurrence of nasal polyposis after polypectomy or ethmoidectomy was studied in 85 patients four years after surgery. The patients were classified into one of three groups according to clinical findings: an atopy group (history confirmed by skin test or nasal provocation), an acetylsalicylic acid intolerance (ASA) group (confirmed by provocation), or an "intrinsic" group (no specific diagnosis). The risk of recurrence was significantly greater in patients with ASA intolerance than in the other two patient groups; the frequency of reoperations during the follow-up period was significantly higher in the ASA group and the need for topical corticosteroid treatment had also been more frequent. Bronchial asthma was diagnosed in 40% of all patients. Asthma was significantly more often associated with ASA group (91%) vs 46% at AT and in only 16% at INTR group.
在85例患者手术后四年，对鼻息肉切除或筛窦切除术后鼻息肉复发情况进行了研究。根据临床检查结果，患者被分为三组之一：特应性组（通过皮肤试验或鼻激发试验确诊病史）、阿司匹林不耐受（ASA）组（通过激发试验确诊）或“内在性”组（无特定诊断）。ASA不耐受患者的复发风险显著高于其他两组患者；随访期间ASA组再次手术的频率显著更高，且局部使用皮质类固醇治疗的需求也更频繁。所有患者中有40%被诊断为支气管哮喘。哮喘与ASA组的关联显著更常见（91%），而在特应性组为46%，在“内在性”组仅为16%。
