Bénoliel P
Allerg Immunol (Paris). 2001 Dec;33(10):388-94.
The NSP is an inflammatory chronic disease of the mucous of nose and sinuses. None etiological treatment is known up to now. The aim of this study is to consider a model of autoallergy as etiology for NSP proven by specific immunotherapy (STI) to Candida albicans (CA).
Four NSP treated by SIT to Candida albicans are reported. The patients are treated either by subcutaneous injections or sublingual drops. The frequency is one injection per week or a few drops per day (absorbed extract on calcium phosphate or aqueous Stallergenes).
The cumulated doses varies from 465 Index of Concentration (IC) to 117500 IC on a period of 3 to 4 years. The results are evaluated according the rhino-sinusal semeiology, the intensity of symptoms, and the stage of polyposis. The SIT is also active on both a late and an immediate components for the symptoms, and the cutaneous tests. The results are significant 60% to 80% of improvement. The viral or bacterial infections reactivate both types of hypersensitivity and they are prevented by SIT. The nasal hyperactivity observed as a more advanced non specific stage of the PNS is also improved by ITS. In two of the clinical cases, the pollenogenic seasonal obstruction is added to the nasal perennial obstruction in a sharp manner. The pollenogenic allergy is also improved after SIT to CA without any other associated SIT.
The model of autoallergy already proven as etiology for atopic dermatitis can serve as a base of exploration of PNS. That is showing the presence of IgE antibody corresponding to intracellular proteinic autoallergens having an analogy to environment allergens. The allergy to Candida albicans can thus be considered as an etiology of the PNS.
鼻息肉病是一种鼻和鼻窦黏膜的炎症性慢性疾病。目前尚无已知的病因治疗方法。本研究的目的是探讨一种自身过敏模型作为鼻息肉病的病因，这一病因已通过对白色念珠菌的特异性免疫疗法（SIT）得到证实。
报告了4例接受白色念珠菌特异性免疫疗法治疗的鼻息肉病患者。患者通过皮下注射或舌下滴剂进行治疗。频率为每周一次注射或每天几滴（磷酸钙吸附提取物或史达优水性提取物）。
在3至4年的时间里，累积剂量从465浓度指数（IC）到117500 IC不等。根据鼻-鼻窦症状学、症状强度和息肉病阶段对结果进行评估。特异性免疫疗法对症状的迟发和速发成分以及皮肤试验也有作用。结果显示有60%至80%的显著改善。病毒或细菌感染会激活两种类型的超敏反应，而特异性免疫疗法可预防这些感染。作为鼻息肉病更晚期非特异性阶段观察到的鼻高反应性也通过特异性免疫疗法得到改善。在两例临床病例中，花粉源性季节性阻塞急剧叠加在常年性鼻阻塞之上。在未进行任何其他相关特异性免疫疗法的情况下，对白色念珠菌进行特异性免疫疗法后，花粉源性过敏也得到了改善。
已被证实为特应性皮炎病因的自身过敏模型可作为鼻息肉病探索的基础。这表明存在与细胞内蛋白质自身变应原相对应的IgE抗体，这些自身变应原与环境变应原具有相似性。因此，对白色念珠菌的过敏可被视为鼻息肉病的一种病因。
