Le Luyer B, Mougenot J F, Mashako L, Chapoy P, Olives J P, Morali A, Chevallier B, Ginies J L, Dupont C, Dagorne M
Département de Pédiatrie, Centre Hospitalier, Le Havre.
Ann Pediatr (Paris). 1992 Dec;39(10):635-40.
An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring. Among the 69 patients in whom endoscopy was carried out before treatment, 18 had erythematous esophagitis and 5 had erosive esophagitis. Irrespective of the dosage used, the frequency of regurgitation and vomiting decreased significantly (p < 0.00001 and p = 0.01, respectively). Clinical and biochemical tolerance were outstanding and no adverse effects were recorded. On the basis of these data, the recommended dosage is 1 to 2 ml/kg/day in divided doses after meals.
开展了一项开放性多中心研究，以评估两种不同剂量的海藻酸对76例经pH监测确诊为胃食管反流的儿科患者的疗效和安全性。在治疗前接受内镜检查的69例患者中，18例有红斑性食管炎，5例有糜烂性食管炎。无论使用何种剂量，反流和呕吐的频率均显著降低（分别为p < 0.00001和p = 0.01）。临床和生化耐受性良好，未记录到不良反应。基于这些数据，推荐剂量为1至2 ml/kg/天，餐后分剂量服用。
