Sexton K, Selevan S G, Wagener D K, Lybarger J A
Office of Health Research, U.S. Environmental Protection Agency, Washington, D.C.
Arch Environ Health. 1992 Nov-Dec;47(6):398-407. doi: 10.1080/00039896.1992.9938381.
Information about human exposures to environmental agents is a crucial component of informed decisions about protection of public health. Results from an inventory of exposure-related databases are used to examine the value of exposure information for risk assessment, risk management, surveillance of status and trends, and epidemiologic studies. Findings indicate that current and future exposure-related databases should include (1) standardized procedures for the collection, storage, analysis, and reporting of data; (2) an enhanced ability to compare data over time, i.e., conduct comparison studies of "old" and "new" methods; (3) mechanisms for coordination and cooperation among public and private-sector organizations with respect to the design, maintenance, exchange, and review of information systems; (4) measurements of actual exposures and dose for relevant human populations; and (5) data collection, storage, and retrieval methods that permit easy manipulation of information for both model building and testing.
有关人类接触环境因素的信息是做出保护公众健康明智决策的关键组成部分。暴露相关数据库清单的结果用于检验暴露信息在风险评估、风险管理、状况和趋势监测以及流行病学研究中的价值。研究结果表明,当前和未来与暴露相关的数据库应包括:(1)数据收集、存储、分析和报告的标准化程序;(2)增强随时间比较数据的能力,即开展“旧”方法与“新”方法的比较研究;(3)公共和私营部门组织在信息系统的设计、维护、交换和审查方面的协调与合作机制;(4)相关人群实际暴露和剂量的测量;以及(5)允许为模型构建和测试轻松处理信息的数据收集、存储和检索方法。