Cardona C J, Bickford A A, Galey F D, Charlton B R, Cooper G
California Veterinary Diagnostic Laboratory System, Turlock Branch, University of California, Davis 95381.
Avian Dis. 1992 Oct-Dec;36(4):1092-101.
A necrotizing skeletal myopathy of rear limbs was diagnosed in 17 flocks of commercial turkeys. The mean mortality attributed to the myopathy was 2.29% (range = 0.13-9.7%) over a mean period of 9.6 days (range = 6-14 days). The mean age of the birds at the time of onset was 7.4 weeks (range = 4-10.5 weeks). Clinically, birds experienced an episode of watery droppings and high-pitched crying, followed by rear-limb paresis or paralysis. Creatine kinase and aspartate aminotransferase were markedly elevated in birds with the myopathy. Grossly, a few birds had pale streaking in the muscles of the thighs and legs. Histologically, acute and subacute degeneration was present in myofibers of the legs, abdomen, thighs, back, and tail. The subacute lesion was characterized by marked sarcolemmal cell proliferation. Feed analyses ruled out selenium deficiency and the presence of mycotoxins as etiologies. Monensin was present in approved usage or only slightly elevated levels. A known potentiating antibiotic was being used concurrently with monensin in only one flock.
在17群商品火鸡中诊断出后肢坏死性骨骼肌病。该病导致的平均死亡率在9.6天（范围为6 - 14天）内为2.29%（范围为0.13 - 9.7%）。发病时鸟类的平均年龄为7.4周（范围为4 - 10.5周）。临床上，鸟类先是出现水样粪便和高声鸣叫，随后后肢轻瘫或瘫痪。患骨骼肌病的鸟类肌酸激酶和天冬氨酸转氨酶显著升高。大体观察，少数鸟类大腿和腿部肌肉有苍白条纹。组织学检查显示，腿部、腹部、大腿、背部和尾部的肌纤维存在急性和亚急性变性。亚急性病变的特征是肌膜细胞显著增殖。饲料分析排除了硒缺乏和霉菌毒素作为病因。莫能菌素的使用量在批准范围内或仅略有升高。仅在一群火鸡中，一种已知的增效抗生素与莫能菌素同时使用。
