Cox A D, Der C J
University of North Carolina, Department of Pharmacology, School of Medicine, Chapel Hill 27599-7365.
Curr Opin Cell Biol. 1992 Dec;4(6):1008-16. doi: 10.1016/0955-0674(92)90133-w.
As with other lipid modifications of proteins, prenylation now appears to be critically important in the regulation of protein function. Recent research has led to an explosion of information concerning prenylation signals, prenyl transferase enzymes and the role of prenylation in protein-membrane interactions. Experiments have examined the role of prenylation in protein function and the results suggest that protein prenylation may be involved in facilitating proper subcellular localization, promoting protein-protein and protein-membrane interactions and regulating protein function.
与蛋白质的其他脂质修饰一样，异戊二烯化目前看来在蛋白质功能调节中至关重要。最近的研究带来了有关异戊二烯化信号、异戊二烯基转移酶以及异戊二烯化在蛋白质-膜相互作用中作用的信息爆炸。实验研究了异戊二烯化在蛋白质功能中的作用，结果表明蛋白质异戊二烯化可能参与促进正确的亚细胞定位、促进蛋白质-蛋白质和蛋白质-膜相互作用以及调节蛋白质功能。
