Christodoulidou F, Silver R T, Macera M J, Verma R S
Division of Hematology/Oncology, Long Island College Hospital--SUNY Health Science Center, Brooklyn 11201.
Cancer Genet Cytogenet. 1992 Dec;64(2):174-7. doi: 10.1016/0165-4608(92)90351-8.
A patient with the typical features of the stable phase of chronic myeloid leukemia (CML) displayed two karyotypically related subclones. In addition to the t(9;22), cells from one clone contained a deletion of the short arm of chromosome 7, del(7)(p12), [46,XY,del(7)(p12),t(9;22)(q34;q11)]; the other contained only the standard translocation [46,XY,t(9;22)(q34;q11)]. Cells with a deletion of the short arm of chromosome 7 at band p12 as the only additional abnormality have not been observed previously in CML. Conventional chemotherapy with hydroxyurea and then with recombinant interferon-alpha (rIFN-alpha) did not reduce the population of either subclone. However, after treatment with a combination of rIFN-alpha and low-dose cytosine arabinoside (LoDac) continuously infused subcutaneously (s.c.), cells from the clone with the deleted chromosome 7 disappeared and normal metaphases were demonstrable.
一名具有慢性髓性白血病（CML）稳定期典型特征的患者表现出两个核型相关的亚克隆。除了t(9;22)外，一个克隆的细胞含有7号染色体短臂缺失，即del(7)(p12)，[46,XY,del(7)(p12),t(9;22)(q34;q11)]；另一个克隆仅含有标准易位[46,XY,t(9;22)(q34;q11)]。7号染色体短臂p12带缺失作为唯一额外异常的细胞此前在CML中尚未观察到。先用羟基脲然后用重组α干扰素（rIFN-α）进行的传统化疗并未减少任一亚克隆的细胞群体。然而，在皮下持续输注rIFN-α和低剂量阿糖胞苷（LoDac）联合治疗后，具有7号染色体缺失的克隆的细胞消失，可检测到正常中期相。
