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A novel translocation involving chromosomes 2, 9, 14, and 22 in chronic myeloid leukemia.

作者信息

Endo K, Sato A, Sugawara T, Kameoka J, Fukuhara O, Meguro K, Shishido T, Abe K

机构信息

Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Cancer Genet Cytogenet. 1995 Apr;80(2):155-7. doi: 10.1016/0165-4608(94)00163-6.

DOI:10.1016/0165-4608(94)00163-6
PMID:7736434
Abstract

A 46-year-old man with chronic myelogenous leukemia was found to have a new complex translocation. In chronic phase, all of the bone marrow cells had a rearrangement of a t(2;9;14;22) (p21;q34;q32;q11). Southern blot analysis of leukocyte DNA revealed rearrangement of the breakpoint cluster region (bcr) within the 5.8-Kb bcr. The patient eventually died in blast crisis 28 months later. The cytogenetic findings of bone marrow cells showed a 46,XY,t(2;9;14;22)(p21;q34;q32;q11),add(1p),del(3q) karyotype in blast crisis.

摘要

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引用本文的文献

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