静脉注射腺苷对人体心房和心室复极的影响。

Effect of intravenous adenosine on human atrial and ventricular repolarisation.

作者信息

Nunain S O, Garratt C, Paul V, Debbas N, Ward D E, Camm A J

机构信息

Department of Cardiological Sciences, St George's Hospital Medical School, London, United Kingdom.

出版信息

Cardiovasc Res. 1992 Oct;26(10):939-43. doi: 10.1093/cvr/26.10.939.

DOI:10.1093/cvr/26.10.939

PMID:1486587

Abstract

OBJECTIVE

The aim was to assess the effects of therapeutic doses of intravenous adenosine on human atrial and ventricular repolarisation.

METHODS

The effects of 6 mg and 12 mg bolus doses of adenosine on the atrial and ventricular monophasic action potentials were studied using the contact catheter technique in 19 patients undergoing routine diagnostic electrophysiology studies. The effect on atrial repolarisation was studied before and after beta blockade in a subgroup of patients.

RESULTS

The duration of the monophasic action potential to 90% repolarisation (MAPD90) was measured in all cases. After 6 mg of adenosine the atrial MAPD90 shortened from 227(SD 29) ms to 188(25) ms (p < 0.005); after 12 mg it shortened from 221(31) ms to 168(32) ms (p < 0.001). The maximum shortening was unaltered by propranolol 0.15 mg.kg-1. The ventricular MAPD90 showed no significant change after 12 mg, at 240(32) ms v 234(33) ms.

CONCLUSIONS

Therapeutic doses of adenosine shorten the atrial but not the ventricular monophasic action potential duration. The effect is dose dependent and not abolished by beta blockade.

摘要

目的

评估治疗剂量的静脉注射腺苷对人心房和心室复极的影响。

方法

采用接触导管技术，对19例接受常规诊断性电生理检查的患者，研究了6毫克和12毫克推注剂量的腺苷对心房和心室单相动作电位的影响。在一个亚组患者中，研究了β受体阻滞剂前后对心房复极的影响。

结果

在所有病例中测量了单相动作电位至90%复极的持续时间（MAPD90）。注射6毫克腺苷后，心房MAPD90从227（标准差29）毫秒缩短至188（25）毫秒（p<0.005）；注射12毫克后，从221（31）毫秒缩短至168（32）毫秒（p<0.001）。最大缩短幅度不受0.15毫克·千克⁻¹普萘洛尔的影响。注射12毫克腺苷后，心室MAPD90无显著变化，分别为240（32）毫秒和234（33）毫秒。