Dutkiewicz T
Department of Clinical Biochemistry and Laboratory Diagnostics, Pomeranian Academy of Medicine, Szczecin, Poland.
Cytobios. 1992;70(282-283):199-202.
Mitochondria are labile objects when isolated from mammalian organs and may undergo rapid changes (aging) in vitro. This work attempts to examine conditions which retard such changes. Isolated rat heart mitochondria were incubated for 180 min in the presence of various substances whose properties might influence the aging process as expressed by changes in oxygen consumption rates. It was found that retardation was greatest with substances which potentially influence reactions involving fatty acids. This effect is discussed in terms of various mechanisms of mitochondrial aging.
从哺乳动物器官中分离出来的线粒体是不稳定的物体，在体外可能会迅速发生变化（老化）。这项工作试图研究延缓这种变化的条件。将分离出的大鼠心脏线粒体在各种物质存在的情况下孵育180分钟，这些物质的性质可能会影响以氧消耗率变化表示的老化过程。结果发现，对涉及脂肪酸的反应有潜在影响的物质延缓老化的效果最为显著。本文从线粒体老化的各种机制方面对这一效应进行了讨论。
