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Reduced mitochondrial DNA transcription in senescent rat heart.

作者信息

Andreu A L, Arbos M A, Perez-Martos A, Lopez-Perez M J, Asin J, Lopez N, Montoya J, Schwartz S

机构信息

Centre d'Investigacions en Bioquímica i Biologia Molecular dels Hospitals Vall d'Hebrón, P. Vall d'Hebrón 119-125, Barcelona, E-08035, Spain.

出版信息

Biochem Biophys Res Commun. 1998 Nov 27;252(3):577-81. doi: 10.1006/bbrc.1998.9703.

DOI:10.1006/bbrc.1998.9703
PMID:9837749
Abstract

We studied the effect of senescence on mitochondrial DNA (mtDNA) transcription with an in organello system using intact isolated rat heart mitochondria. A comparison of the electrophoretic patterns of mtDNA transcription products in young, adult and senescent rats showed an age-related reduction in newly-synthesized mitochondrial RNAs that reflects a decrease in the synthesis rate. These results correlate with the enzyme activities of the oxidative phosphorylation complexes I and IV, that are partially encoded by the mitochondrial genome. In addition, an age-related increase in the protein carbonyl content of the mitochondrial membranes was observed in senescent mitochondria suggesting an accumulation of mitochondrial oxidative damage. This reduction in the mtDNA transcriptional rate in the heart of senescent animals suggests that this could be one of the molecular bases underlying senescence of the myocardium.

摘要

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