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The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin.

作者信息

Jirik F R, Harder K W, Melhado I G, Anderson L L, Duncan A M

机构信息

Biomedical Research Centre, University of British Columbia, Vancouver, Canada.

出版信息

Cytogenet Cell Genet. 1992;61(4):266-8. doi: 10.1159/000133418.

DOI:10.1159/000133418
PMID:1486801
Abstract

In situ hybridization was employed to localize a cDNA probe from the human protein tyrosine phosphatase gene LAR to human metaphase chromosomes. LAR, a putative tumor suppressor gene, has been localized to 1p32, a chromosomal region that is frequently found deleted in human neuroblastoma and pheochromocytoma.

摘要

相似文献

1
The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin.
Cytogenet Cell Genet. 1992;61(4):266-8. doi: 10.1159/000133418.
2
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.白细胞共同抗原相关酪氨酸磷酸酶受体:在表现出自发性嗜铬细胞瘤的新英格兰女执事医院大鼠品系中mRNA和蛋白质表达的改变。
Carcinogenesis. 2000 Feb;21(2):125-31. doi: 10.1093/carcin/21.2.125.
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Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression.白细胞共同抗原相关受体连接的酪氨酸磷酸酶。mRNA表达的调控。
J Biol Chem. 1993 Dec 15;268(35):26503-11.
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The human protein-tyrosine phosphatase PTP alpha/LRP gene (PTPA) is assigned to chromosome 20p13.人类蛋白酪氨酸磷酸酶PTPα/LRP基因(PTPA)定位于20号染色体短臂13区。
Cytogenet Cell Genet. 1992;60(2):117-8. doi: 10.1159/000133317.
5
Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins.白细胞共同抗原相关蛋白对RET-MEN2A和RET-MEN2B突变蛋白的生化及生物学活性的不同影响。
J Biol Chem. 2001 Mar 23;276(12):9460-7. doi: 10.1074/jbc.M008744200. Epub 2000 Dec 19.
6
Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line.在一个小细胞肺癌细胞系中,1p32染色体上编码蛋白酪氨酸磷酸酶LAR和L-myc的基因(PTPRF和MYCL1)共存扩增。
Genomics. 1995 Jun 10;27(3):552-3. doi: 10.1006/geno.1995.1092.
7
Loss of heterozygosity on the short arm of chromosome 1 in pheochromocytoma and abdominal paraganglioma.嗜铬细胞瘤和腹部副神经节瘤中1号染色体短臂杂合性缺失
World J Surg. 2002 Aug;26(8):965-71. doi: 10.1007/s00268-002-6626-8. Epub 2002 Jun 6.
8
Fine analysis of the short arm of chromosome 1 in sporadic and familial pheochromocytoma.散发性和家族性嗜铬细胞瘤中1号染色体短臂的精细分析
Clin Endocrinol (Oxf). 2003 Dec;59(6):707-15. doi: 10.1046/j.1365-2265.2003.01910.x.
9
Deletion mapping in breast tumor cell lines points to two distinct tumor-suppressor genes in the 1p32-pter region, one of deleted regions (1p36.2) being located within the consensus region of LOH in neuroblastoma.
Oncol Rep. 1998 Jan-Feb;5(1):267-72. doi: 10.3892/or.5.1.267.
10
Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p.使用覆盖1号染色体短臂的0.1 - 0.2 Mb细菌人工染色体阵列对散发性和综合征相关嗜铬细胞瘤进行基于微阵列的比较基因组杂交分析。
Genes Chromosomes Cancer. 2006 Jan;45(1):83-93. doi: 10.1002/gcc.20268.

引用本文的文献

1
Receptor-like protein tyrosine phosphatases: alike and yet so different.受体样蛋白酪氨酸磷酸酶:相似却又如此不同。
Mol Biol Rep. 1997 Nov;24(4):247-62. doi: 10.1023/a:1006870016238.
2
LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats.LAR酪氨酸磷酸酶受体:可变剪接在神经系统中更为优先,与细胞生长协调,并产生含有大量CAG重复序列的新型异构体。
J Cell Biol. 1995 Feb;128(3):415-31. doi: 10.1083/jcb.128.3.415.