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受体样蛋白酪氨酸磷酸酶：相似却又如此不同。

Receptor-like protein tyrosine phosphatases: alike and yet so different.

作者信息

Schaapveld R, Wieringa B, Hendriks W

机构信息

Department of Cell Biology & Histology, Institute of Cellular Signalling, University of Nijmegen, The Netherlands.

出版信息

Mol Biol Rep. 1997 Nov;24(4):247-62. doi: 10.1023/a:1006870016238.

DOI:10.1023/a:1006870016238
PMID:9403867
Abstract

Reversible phosphorylation on tyrosine residues is an extremely rapid and powerful posttranslational modification that is used in signalling pathways for the regulation of cell growth and differentiation. Over the past several years an impressive number of receptor-like protein tyrosine phosphatase (RPTPase) family members have been identified by molecular cloning, and undoubtedly many more will follow. This review provides an overview of the molecular data that are available for the currently identified RPTPases and discusses their possible biological implications.

摘要

酪氨酸残基上的可逆磷酸化是一种极其快速且强大的翻译后修饰，用于细胞生长和分化调节的信号通路中。在过去几年里，通过分子克隆已经鉴定出了数量可观的受体样蛋白酪氨酸磷酸酶（RPTPase）家族成员，毫无疑问，后续还会发现更多。本综述概述了目前已鉴定的RPTPases的分子数据，并讨论了它们可能的生物学意义。

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蛋白质酪氨酸磷酸酶在调节胰岛素信号传导中的作用及其在肥胖相关胰岛素抵抗发病机制中的意义。
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Receptor-type Protein tyrosine phosphatase β regulates met phosphorylation and function in head and neck squamous cell carcinoma.受体型蛋白酪氨酸磷酸酶β调控头颈部鳞状细胞癌中的 MET 磷酸化和功能。
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