Dodrill C B
Regional Epilepsy Center, University of Washington School of Medicine, Seattle.
Epilepsia. 1992;33 Suppl 6:S29-32.
The major problems in the study of the cognitive effects of antiepileptic drugs (AEDs) are explored. These problems include subject selection factors, statistical difficulties, matters pertaining to choice of cognitive tests, and the impacts of seizures on performance. A tendency is noted for these contaminating factors to result in attributing to AEDs adverse changes that might more accurately be related to other causes. Although all of these active central nervous system medications likely have some adverse cognitive effects, at least at high levels, the magnitude of these effects may have been exaggerated in the past. This is confirmed by more recent and better-controlled investigations.
探讨了抗癫痫药物（AEDs）认知效应研究中的主要问题。这些问题包括受试者选择因素、统计困难、认知测试选择相关事项以及癫痫发作对表现的影响。注意到这些混杂因素有导致将可能更准确地归因于其他原因的不良变化归咎于AEDs的趋势。尽管所有这些作用于中枢神经系统的药物可能都有一些不良认知效应，至少在高剂量时如此，但这些效应的程度在过去可能被夸大了。最近进行的更好控制的研究证实了这一点。
