Dodrill C B
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA.
J Clin Psychiatry. 1988 Apr;49 Suppl:31-4.
The selection of antiepileptic drugs depends not just on efficacy considerations but on psychological side effects, including their effects on abilities. In general, investigations show that antiepileptic drugs have slight to mild adverse effects on abilities. Of the major agents, carbamazepine is frequently associated with fewer of these effects. There are, however, a number of confounding factors which complicate the interpretation of these studies. These include procedures pertaining to subject selection, statistical analysis, seizures, co-medication, test selection, and the use of the active agent versus placebo study design. The importance of each of these factors is briefly discussed, with emphasis on their relevance to interpretation of existing studies.
抗癫痫药物的选择不仅取决于疗效，还取决于心理副作用，包括对能力的影响。一般来说，研究表明抗癫痫药物对能力有轻微至中度的不良影响。在主要药物中，卡马西平通常较少出现这些影响。然而，有许多混杂因素使这些研究的解读变得复杂。这些因素包括与受试者选择、统计分析、癫痫发作、联合用药、测试选择以及活性药物与安慰剂研究设计的使用有关的程序。本文简要讨论了每个因素的重要性，重点强调了它们与现有研究解读的相关性。
