Represa A, Ben-Ari Y
INSERM U29, Paris, France.
Exp Brain Res. 1992;92(1):69-78. doi: 10.1007/BF00230384.
A Golgi and electron microscopy study of the hippocampal CA3 region was performed on control and kindled Wistar rats. The observations provide evidence that, in epileptic rats, mossy fibres sprout and establish novel synapses with the basilar dendrites of CA3 pyramidal neurons. These newly-developed synapses showed the typical features of mossy synapses observed in the stratum lucidum, including the appearance of complex giant spines. The morphological changes reported here may represent a histopathological substrate for the epilepsy in the absence of overt signs of a hippocampal lesion.
对对照和点燃的Wistar大鼠进行了海马CA3区的高尔基和电子显微镜研究。观察结果提供了证据，即在癫痫大鼠中，苔藓纤维发芽并与CA3锥体神经元的基底树突建立新的突触。这些新形成的突触表现出在透明层中观察到的苔藓突触的典型特征，包括复杂巨型棘的出现。这里报道的形态学变化可能代表了在没有明显海马病变迹象的情况下癫痫的组织病理学基础。
