Jacobson G P, Lombardi D M, Gibbens N D, Ahmad B K, Newman C W
Department of Neurology, Henry Ford Hospital, Detroit, Michigan.
Ear Hear. 1992 Oct;13(5):300-6. doi: 10.1097/00003446-199210000-00007.
Magnetoencephalographic (MEG) applications in auditory evoked field (AEF) recordings have demonstrated that both tonotopicity and amplitopicity exist in the auditory cortex. The present study was conducted to determine whether previously reported characteristics of the AEF could be identified in multichannel cortical auditory evoked potential N1e (e.g., the electrical correlate of the magnetically recorded N1m) component recordings. Multichannel auditory evoked potentials from 11 young normal adults were collected after monaural tone burst stimuli of 250, 1000, and 4000 Hz. Results demonstrated that N1e amplitudes after stimulation at 250 Hz were significantly larger than those obtained after stimulation at 1000 or 4000 Hz. These frequency-specific differences existed for latency as well. Responses obtained after stimulation at 250 Hz were, on the average, 13 msec longer than those obtained after stimulation at 1000 or 4000 Hz. Also, contralateral latencies were significantly shorter than ipsilateral latencies. Although the significant frequency-specific amplitude results support the findings of previous investigators, the frequency-related latency differences have not been described. An explanation of these differences may exist in the spatial differences in the reception areas for low- and high-frequency tones in the primary auditory cortex.
脑磁图（MEG）在听觉诱发电场（AEF）记录中的应用表明，听觉皮层中存在音调定位和振幅定位。本研究旨在确定在多通道皮层听觉诱发电位N1e（例如，磁记录的N1m的电相关成分）记录中是否能够识别出先前报道的AEF特征。在对11名年轻正常成年人进行250、1000和4000 Hz的单耳短纯音刺激后，收集多通道听觉诱发电位。结果表明，250 Hz刺激后的N1e振幅显著大于1000或4000 Hz刺激后的振幅。这些频率特异性差异在潜伏期也存在。250 Hz刺激后获得的反应平均比1000或4000 Hz刺激后获得的反应长13毫秒。此外，对侧潜伏期明显短于同侧潜伏期。虽然频率特异性振幅的显著结果支持了先前研究者的发现，但频率相关的潜伏期差异尚未被描述。这些差异的解释可能存在于初级听觉皮层中低频和高频音调接收区域的空间差异中。
