Cantu Edward, Parker William, Platt Jeffrey L, Duane Davis R
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Am J Transplant. 2004;4 Suppl 6:25-35. doi: 10.1111/j.1600-6135.2004.0342.x.
As one approach to circumventing the dire shortage of human lungs for transplantation, a handful of investigators have begun to probe the possibility of pulmonary xenotransplantation. The immunologic and perhaps physiologic barriers encountered by these investigators are considerable and progress in pulmonary xenotransplantation has lagged behind progress in cardiac and kidney xenotransplantation. However, during the last few years there have been substantial advances in the field of pulmonary xenotransplantation including, most noticeably, significant progress in attenuating hyperacute dysfunction. Progress has been made in understanding the barriers imposed by xenoreactive antibodies, complement, coagulation incompatibility and porcine pulmonary intravascular macrophages. Although our understanding of the barriers to pulmonary xenotransplantation is far from complete and the clinical application of pulmonary xenotransplantation is not yet in sight, current progress is fast paced. This progress provides a basis for future work and for a hope that the shortage of human lungs for transplantation will not always be a matter of life and death.
作为应对移植用人类肺脏严重短缺的一种方法，一些研究人员已开始探索肺异种移植的可能性。这些研究人员遇到的免疫以及可能存在的生理障碍相当大，肺异种移植的进展落后于心脏和肾脏异种移植。然而，在过去几年中，肺异种移植领域取得了重大进展，最显著的是在减轻超急性功能障碍方面取得了重大进展。在了解异种反应性抗体、补体、凝血不相容性和猪肺血管内巨噬细胞所造成的障碍方面也取得了进展。尽管我们对肺异种移植障碍的理解还远未完善，肺异种移植的临床应用也尚未在望，但目前进展迅速。这一进展为未来的工作提供了基础，也带来了一种希望，即移植用人类肺脏短缺不会永远是生死攸关的问题。
