无痴呆帕金森病患者清醒脑电图减慢与快速眼动睡眠行为障碍之间的关联
Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia.
作者信息
Gagnon J-F, Fantini M L, Bédard M-A, Petit D, Carrier J, Rompré S, Décary A, Panisset M, Montplaisir J
机构信息
Centre d'étude du sommeil et des rythmes biologiques, Hôpital du Sacré-Coeur de Montréal, Canada.
出版信息
Neurology. 2004 Feb 10;62(3):401-6. doi: 10.1212/01.wnl.0000106460.34682.e9.
OBJECTIVE
To compare nondemented patients with Parkinson's disease (PD) with and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness and REM sleep.
METHODS
Fifteen patients with PD (7 patients with polysomnographic-confirmed RBD [PD-RBD] and 8 patients without RBD [PD-NRBD]) and 15 healthy control subjects were studied. Each subject underwent a quantitative EEG analysis of both wakefulness and REM sleep.
RESULTS
During wakefulness, patients with PD-RBD showed a higher theta power in frontal, parietal, temporal, and occipital regions in comparison to patients with PD-NRBD and control subjects. Moreover, a slowing of the dominant occipital frequency was observed only in patients with PD-RBD (p < 0.02). Patients with PD-NRBD did not present any slowing of the EEG. No between-group difference in quantitative REM sleep EEG was observed.
CONCLUSIONS
This study demonstrates that the EEG slowing reported during wakefulness in nondemented patients with PD is strongly related to the presence of RBD.
目的
比较患有快速眼动睡眠行为障碍（RBD）和未患RBD的非痴呆帕金森病（PD）患者与健康对照者在清醒和快速眼动睡眠状态下的定量脑电图特征。
方法
对15例PD患者（7例经多导睡眠图确诊为RBD的患者[PD-RBD]和8例未患RBD的患者[PD-NRBD]）以及15名健康对照者进行研究。每位受试者均接受了清醒和快速眼动睡眠状态下的定量脑电图分析。
结果
在清醒状态下，与PD-NRBD患者和对照者相比，PD-RBD患者在额叶、顶叶、颞叶和枕叶区域表现出更高的θ波功率。此外，仅在PD-RBD患者中观察到优势枕叶频率减慢（p < 0.02）。PD-NRBD患者未出现脑电图减慢。在定量快速眼动睡眠脑电图方面未观察到组间差异。
结论
本研究表明，非痴呆PD患者在清醒状态下报告的脑电图减慢与RBD的存在密切相关。
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