Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada; Department of Psychology, Université de Montréal, Montreal, Quebec, Canada.
Sleep Med. 2013 Nov;14(11):1059-63. doi: 10.1016/j.sleep.2013.06.013. Epub 2013 Sep 8.
Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a well-documented risk factor for synucleinopathies such as Parkinson disease (PD) and dementia with Lewy bodies (DLB). Moreover, approximately 50% of iRBD patients have mild cognitive impairment (MCI). The purpose of our study was to investigate waking electroencephalogram (EEG) abnormalities specific to iRBD patients with MCI.
Forty-two polysomnographically confirmed iRBD patients, including 23 iRBD [+]MCI patients 19 patients without MCI (iRBD [-]MCI), and 37 healthy subjects participated in the study. All participants underwent a complete neuropsychologic assessment for MCI diagnosis and a waking quantitative EEG recording.
iRBD [+]MCI patients had a higher slow-to-fast frequency ratio than iRBD [-]MCI patients and controls in the parietal, temporal, and occipital regions. iRBD [+]MCI patients also had higher relative θ power in the parietal, temporal, and occipital regions and lower relative α power in the occipital region compared to iRBD [-]MCI patients and controls. Moreover, iRBD [+]MCI patients had higher relative θ power in the frontal and central areas and lower relative β power in the central, parietal, and temporal regions compared to controls. The dominant occipital frequency also was slower in iRBD [+]MCI patients compared to controls. No between-group differences were observed between iRBD [-]MCI patients and controls.
In iRBD patients, only those with concomitant MCI showed waking EEG slowing in the posterior cortical regions, providing a potential marker for an increased risk for developing DLB or PD.
特发性快速眼动（REM）睡眠行为障碍（iRBD）是一种众所周知的突触核蛋白病的风险因素，如帕金森病（PD）和路易体痴呆（DLB）。此外，约 50%的 iRBD 患者有轻度认知障碍（MCI）。我们的研究目的是探讨伴有 MCI 的 iRBD 患者的清醒脑电图（EEG）异常。
42 例经多导睡眠图证实的 iRBD 患者，包括 23 例 iRBD [+]MCI 患者、19 例无 MCI（iRBD [-]MCI）患者和 37 例健康对照者参与了研究。所有参与者均接受了全面的神经心理学评估，以确定 MCI 的诊断，并进行了清醒的定量 EEG 记录。
iRBD [+]MCI 患者的顶、颞、枕叶区域的慢波至快波频率比高于 iRBD [-]MCI 患者和对照组。与 iRBD [-]MCI 患者和对照组相比，iRBD [+]MCI 患者的顶、颞、枕叶区域的相对θ功率较高，枕叶区域的相对α功率较低。此外，iRBD [+]MCI 患者的额、中央区域的相对θ功率较高，中央、顶、颞叶区域的相对β功率较低。与对照组相比，iRBD [+]MCI 患者的优势枕叶频率也较慢。iRBD [-]MCI 患者与对照组之间无组间差异。
在 iRBD 患者中，只有那些同时伴有 MCI 的患者在后皮质区域出现清醒 EEG 减慢，这可能是发生 DLB 或 PD 的风险增加的一个潜在标志物。
