Geyer O, Loewenstein A, Gertler-Hertz I, Lazar M
Dept. of Ophthalmology, Ichilov Hospital, Tel Aviv.
Harefuah. 1992 Dec 1;123(11):460-1, 506.
Topically-administered ophthalmic medication may reach clinically significant serum concentrations, as evidenced by the variety of systemic side effects reported. These drugs may interact with other drugs administered orally and intravenously, increasing the frequency and severity of their side-effects. We report 4 patients examined in the emergency room because of various systemic manifestations, in whom the symptoms could be attributed either to antiglaucomatous eye drops, or to interaction between these eye drops and systemic medication. Considering the high incidence of glaucoma (0.5-2%), physicians should be aware of the systemic side-effects of antiglaucomatous eye drops and of possible interaction between such treatment and systemic medications.
局部应用的眼科药物可能会达到具有临床意义的血清浓度，各种报告的全身性副作用就证明了这一点。这些药物可能会与口服和静脉注射的其他药物相互作用，增加其副作用的频率和严重程度。我们报告了4例因各种全身表现而在急诊室接受检查的患者，其症状可能归因于抗青光眼滴眼液，或这些滴眼液与全身用药之间的相互作用。考虑到青光眼的高发病率（0.5%-2%），医生应了解抗青光眼滴眼液的全身副作用以及这种治疗与全身用药之间可能存在的相互作用。
