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腹主动脉瘤

Abdominal aortic aneurysm.

作者信息

Prisant L Michael, Mondy J Sheppard

机构信息

Department of Hypertension, Medical College of Georgia, Augusta, GA 30912, USA.

出版信息

J Clin Hypertens (Greenwich). 2004 Feb;6(2):85-9. doi: 10.1111/j.1524-6175.2004.02838.x.

Abstract

An abdominal aortic aneurysm (AAA) is defined as a localized dilation of the artery that is 1.5 times the diameter of the normal segment. The most common location for an aortic aneurysm is the infrarenal segment where a diameter that exceeds 3 cm in diameter is considered aneurysmal. Duplex ultrasonography and spiral computerized tomography are the imaging modalities most commonly performed to detect the longitudinal and transverse diameter of the aorta. The prevalence of AAA may be increasing. Smoking, male gender, and increasing age are the most powerful predictors of AAA. Considering the higher prevalence of hypertension, it is surprising that the prevalence of AAA among African-American men is 39% less than white men. The risk of rupture is independently associated with female gender, large initial aneurysm diameter, lower forced expiratory volume in the first second, current smoking, and higher mean blood pressure. Inflammation rather than atherosclerosis may be essential to the development of AAA. Treatment is directed at smoking cessation and control of blood pressure and lipids. Beta blockers (propranolol) have not been shown to modify aneurysm growth rates, but drop out rates in the studies have been high. Antibiotics do show a modest benefit. Surgery is generally performed when the aneurysm exceeds 5.5 cm in men. For women, an AAA size between 4.5 cm and 5.0 cm is recommended for elective repair.

摘要

腹主动脉瘤(AAA)被定义为动脉的局限性扩张,其直径是正常节段直径的1.5倍。主动脉瘤最常见的部位是肾下段,直径超过3 cm被认为是动脉瘤性的。双功超声和螺旋计算机断层扫描是最常用于检测主动脉纵径和横径的成像方式。AAA的患病率可能在上升。吸烟、男性性别和年龄增长是AAA最有力的预测因素。考虑到高血压患病率较高,非裔美国男性AAA患病率比白人男性低39%这一点令人惊讶。破裂风险与女性性别、初始动脉瘤直径较大、第一秒用力呼气量较低、当前吸烟以及平均血压较高独立相关。炎症而非动脉粥样硬化可能是AAA发生发展的关键因素。治疗旨在戒烟以及控制血压和血脂。β受体阻滞剂(普萘洛尔)尚未显示能改变动脉瘤生长速度,但研究中的退出率较高。抗生素确实显示出一定益处。男性动脉瘤超过5.5 cm时一般进行手术。对于女性,AAA大小在4.5 cm至5.0 cm之间建议进行择期修复。

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