Bhaumik Urmi, Aitken Iain, Kawachi Ichiro, Ringer Steve, Orav John, Lieberman Ellice
Department of Maternal and Child Health, Harvard School of Public Health, Boston, MA 02115, USA.
J Perinatol. 2004 Feb;24(2):94-9. doi: 10.1038/sj.jp.7211021.
To examine whether the improved survival of preterm infants has influenced the known male excess in infant mortality.
We analyzed sex-specific infant mortality using linked birth and death certificates for all 619,811 live born infants in Massachusetts between 1989 and 1995.
Between 1989 and 1995 the male excess in infant mortality decreased by 50%, from 1.6/1000 to 0.8/1000 live births (LB). This narrowing resulted primarily from a more rapid decline in neonatal mortality among male infants (1.5/1000 LB) than among female infants (0.9/1000 LB). The largest declines in the male excess in neonatal mortality occurred among very premature infants (GA < or = 30 weeks) and resulted primarily from a more rapid decrease in male deaths from respiratory distress syndrome.
The narrowing of the sex difference in mortality between 1989 and 1995 suggests that newer treatments like antenatal steroids, and surfactants may have differentially benefited male infants.
探讨早产婴儿存活率的提高是否影响了已知的男婴在婴儿死亡率方面的超额情况。
我们利用1989年至1995年间马萨诸塞州619,811名活产婴儿的出生与死亡证明的关联数据,分析了按性别划分的婴儿死亡率。
1989年至1995年间,男婴在婴儿死亡率方面的超额情况下降了50%,从每1000例活产中有1.6例降至0.8例。这种差距缩小主要是因为男婴新生儿死亡率(每1000例活产中有1.5例)的下降速度比女婴(每1000例活产中有0.9例)更快。男婴在新生儿死亡率方面超额情况下降幅度最大的是极早产儿(孕周≤30周),主要原因是呼吸窘迫综合征导致的男婴死亡下降速度更快。
1989年至1995年间死亡率性别差异的缩小表明,诸如产前类固醇和表面活性剂等新疗法可能对男婴有不同程度的益处。