Levrier J, Duval D, Lloyd K G
Synthelabo Recherche, (LERS) Biology Department, Bagneux, France.
Fundam Clin Pharmacol. 1992;6(6):231-6. doi: 10.1111/j.1472-8206.1992.tb00115.x.
In order to study the physiological correlates of the beneficial action of carbocisteine (S-carboxy-methyl-cysteine), we have measured the changes occurring in ventilatory parameters in rats made bronchitic by prolonged exposure (2 weeks) to air containing sulfur dioxide (SO2). In animals treated with distilled water (1 ml/100 g/day), statistically significant (P < 0.05) changes in respiratory frequency (-20%) and tidal volume (+31%) were found. As a result of these opposing changes, the ventilation/min was stable. Moreover, the compliance was decreased (33%, P < 0.05) and the resistance was greatly enhanced (+ 99%, P < 0.05). The concomitant administration of carbocisteine (500 mg/kg po/day) with SO2 inhalation significantly (P < 0.05) prevented the development of resistance without effecting significant changes in the other parameters except for a slight improvement in ventilation/min. In conclusion, this improved respiratory resistance in the bronchitic carbocisteine-treated animals tallies with a decrease in mucus retention associated with the return to normal of rheological characteristics of the secreted mucus.
为了研究羧甲司坦（S-羧甲基半胱氨酸）有益作用的生理相关性，我们测量了通过长时间（2周）暴露于含二氧化硫（SO₂）的空气中而诱发支气管炎的大鼠通气参数的变化。在用蒸馏水治疗的动物（1毫升/100克/天）中，发现呼吸频率（-20%）和潮气量（+31%）有统计学意义（P<0.05）的变化。由于这些相反的变化，每分钟通气量保持稳定。此外，顺应性降低（33%，P<0.05），阻力大大增加（+99%，P<0.05）。在吸入SO₂的同时给予羧甲司坦（500毫克/千克口服/天）可显著（P<0.05）预防阻力的增加，除了每分钟通气量略有改善外，对其他参数没有显著影响。总之，羧甲司坦治疗的支气管炎动物呼吸阻力的改善与黏液潴留的减少以及分泌黏液流变学特性恢复正常有关。
