Zahm J M, Levrier J, Duval D, Pierrot D, Puchelle E
INSERM U 314, CHR Maison Blanche, Reims, France.
Fundam Clin Pharmacol. 1993;7(3-4):155-60. doi: 10.1111/j.1472-8206.1993.tb00229.x.
In order to study the effect of carbocisteine on the mucociliary function of the respiratory tract, we performed a double-blind study on rats with SO2-induced (400 ppm) hypersecretion. During the experimental bronchitis, the treated group of rats received carbocisteine through a stomach tube at a dose level of 500 mg/kg for 15 days, whereas the untreated group of rats received distilled water. After killing the rats, and following lung excision, the respiratory mucus was scraped off and collected by using a glass capillary. The mucus degree of purulence was macroscopically estimated and the mucus transport rate was measured by using the frog palate technique. The mean mucus relative transport rate, measured on the frog palate, was 0.60 +/- 0.17 in the untreated group and was significantly higher (P < 0.01) in the treated group (0.73 +/- 0.14). Carbocisteine also significantly altered (P < 0.01) the mucus macroscopical aspect, leading to a decrease in the number of rats with purulent mucus. These results suggest that carbocisteine maintains an efficient mucus transport rate, leading to a less infected respiratory tract.
为了研究羧甲司坦对呼吸道黏液纤毛功能的影响，我们对二氧化硫诱导（400 ppm）分泌亢进的大鼠进行了一项双盲研究。在实验性支气管炎期间，治疗组大鼠通过胃管以500 mg/kg的剂量水平给予羧甲司坦，持续15天，而未治疗组大鼠给予蒸馏水。处死大鼠后，切除肺脏，用玻璃毛细管刮取并收集呼吸道黏液。肉眼评估黏液的脓性程度，并采用蛙腭技术测量黏液转运速率。在未治疗组中，蛙腭上测得的平均黏液相对转运速率为0.60±0.17，治疗组显著更高（P<0.01）（0.73±0.14）。羧甲司坦还显著改变了（P<0.01）黏液的宏观外观，导致脓性黏液大鼠数量减少。这些结果表明，羧甲司坦可维持有效的黏液转运速率，使呼吸道感染减轻。
