Kilpatrick D C
Department of Transfusion Medicine, Edinburgh, Scotland.
Immunol Lett. 1992 Dec;34(3):201-6. doi: 10.1016/0165-2478(92)90214-9.
The relationship between soluble interleukin-2 receptors (IL-2R) and pregnancy outcome was investigated in women with a history of miscarriage, some of whom were treated with partner-specific leukocyte immunotherapy. IL-2R were significantly elevated in patients with a poor obstetric history possessing cardiolipin antibodies, and higher levels were also found in recurrent aborters without cardiolipin antibodies who had particularly bad histories. Furthermore, values obtained during early pregnancy were lower in patients who subsequently had successful pregnancies than in those who aborted again. Eight out of 35 patients immunised with their partners' lymphocytes, but none of 16 patients immunised with their own cells, showed a marked decrease in IL-2R levels a month later. It is possible that the minority who respond to immunotherapy with a marked drop in IL-2R may be the same minority who may derive benefit from this treatment.
我们调查了有流产史女性的可溶性白细胞介素-2受体（IL-2R）与妊娠结局之间的关系，其中一些女性接受了配偶特异性白细胞免疫疗法。产科病史不良且患有心磷脂抗体的患者中，IL-2R显著升高；在无 心磷脂抗体但流产史特别糟糕的反复流产患者中也发现了较高水平的IL-2R。此外，随后成功妊娠的患者在孕早期测得的数值低于再次流产的患者。35例接受配偶淋巴细胞免疫的患者中，有8例在一个月后IL-2R水平显著下降，但16例接受自身细胞免疫的患者中无一例出现这种情况。有可能对免疫疗法有反应且IL-2R显著下降的少数患者，可能就是能从这种治疗中获益的同一批少数患者。
