Tulppala M, Ailus K, Palosuo T, Ylikorkala O
Department I of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.
Fertil Steril. 1995 Nov;64(5):947-50. doi: 10.1016/s0015-0282(16)57907-2.
To determine the occurrence of antibodies to oxidized low-density lipoprotein (LDL) in women with a history of habitual abortion before and during pregnancy.
Immunoglobulin G class antibodies to malondialdehyde modified LDL were determined by a solid-phase ELISA in 42 habitual aborters before pregnancy, in 39 patients during pregnancy, and in 23 comparable nonpregnant and 22 pregnant control women without a history of abortion. In addition, we assessed the presence of anticardiolipin antibodies by ELISA in the same sera.
Departments I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Helsinki, Finland.
Early pregnancy was accompanied by a decrease in the median levels of antibodies to oxidized LDL both in habitual aborters and in the control series. Only one patient exhibited a raised level of antibodies to oxidized LDL before pregnancy but, during pregnancy, nine patients (23%) had elevated levels of antibodies to oxidized LDL, similar to women with a favorable outcome of pregnancy (6/27, 22%) and in women whose current pregnancy also ended in abortion (3/12, 25%). Cardiolipin binding antibodies were detected in three habitual aborters before pregnancy (7%) and in nine women during pregnancy (23%), with a tendency to be more frequent in patients with miscarrying pregnancies than in those with continuing pregnancies (4/12, 33% and 5/27, 19%). Antibodies to oxidized LDL and cardiolipin were simultaneously present in three habitual aborters with continuing pregnancies.
Increased levels of antibodies to oxidized LDL and cardiolipin may be associated with habitual abortion.
确定有习惯性流产史的女性在孕前及孕期氧化型低密度脂蛋白（LDL）抗体的出现情况。
采用固相酶联免疫吸附测定法（ELISA），检测42例有习惯性流产史女性的孕前丙二醛修饰LDL的免疫球蛋白G类抗体，39例患者孕期抗体，23例无流产史的非孕对照女性及22例无流产史的孕龄对照女性的抗体。此外，采用ELISA法检测同一血清样本中的抗心磷脂抗体。
芬兰赫尔辛基大学中心医院妇产科一、二病区。
习惯性流产组及对照组在孕早期氧化型LDL抗体的中位数水平均下降。仅1例患者孕前氧化型LDL抗体水平升高，但孕期有9例患者（23%）氧化型LDL抗体水平升高，与妊娠结局良好的女性（6/27，22%）及此次妊娠仍以流产告终的女性（3/12，25%）相似。孕前3例习惯性流产患者（7%）及孕期9例女性（23%）检测到心磷脂结合抗体，流产患者的心磷脂结合抗体出现频率高于继续妊娠患者（4/12，33%和5/27，19%）。3例继续妊娠的习惯性流产患者同时存在氧化型LDL抗体和心磷脂抗体。
氧化型LDL抗体和心磷脂抗体水平升高可能与习惯性流产有关。
