牛蛙中血红蛋白的变态
The metamorphosis of hemoglobin in the bullfrog.
作者信息
RIGGS A
出版信息
J Gen Physiol. 1951 Sep;35(1):23-40. doi: 10.1085/jgp.35.1.23.
Abstract
- Tadpole and adult hemoglobin do not differ significantly in molecular weight. The molecular weight of both is in the neighborhood of 68,000. 2. Heme-heme interaction as measured by the value of n in Hill's equation is virtually the same-about 2.8-in both tadpole and adult. 3. There appears to be no significant effect of pH upon the oxygen equilibrium of tadpole hemoglobin, in contrast to large Bohr and reverse Bohr effects in the adult. This is taken to mean that during metamorphosis acid groups of globin become sensitive to the oxygenation of heme by some change in the mode of linkage between heme and globin. 4. The oxygen affinity of tadpole hemoglobin is about seven times as great as that of the adult at pH 6 and twice as great at pH 9.
摘要
- 蝌蚪血红蛋白和成年血红蛋白的分子量没有显著差异。两者的分子量都在68,000左右。2. 通过希尔方程中的n值衡量的血红素-血红素相互作用在蝌蚪和成年个体中实际上是相同的——约为2.8。3. 与成年个体中较大的玻尔效应和反向玻尔效应相反，pH对蝌蚪血红蛋白的氧平衡似乎没有显著影响。这被认为意味着在变态过程中，球蛋白的酸性基团通过血红素与球蛋白之间连接方式的某种变化而对血红素的氧合变得敏感。4. 在pH 6时，蝌蚪血红蛋白的氧亲和力约为成年个体的七倍，在pH 9时为成年个体的两倍。
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