切断的周围神经远侧断端对轴突再生的神经营养影响：成年神经中不存在拓扑特异性。
Neurotropic influence of the distal stump of transected peripheral nerve on axonal regeneration: absence of topographic specificity in adult nerve.
作者信息
Abernethy D A, Rud A, Thomas P K
机构信息
Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
出版信息
J Anat. 1992 Jun;180 ( Pt 3)(Pt 3):395-400.
Abstract
Observations have been made on the growth of regenerating axons from transected rat sciatic nerve through Y-shaped silicone tubes. When the distal stump of the nerve was sutured into 1 distal limb of the tube and a fat pad into the other, a clear preference for the axons to regenerate towards the distal stump was found. In other experiments regenerating axons from the peroneal or tibial divisions of the sciatic nerve were given the choice of growing towards either the peroneal or tibial nerves, each being inserted into 1 of the 2 distal limbs of the Y-tube. No significant preference of the proximal stump to regenerate towards its appropriate distal stump was detected. A neurotropic influence of the distal stump on the nerve has therefore been confirmed, but topographic specificity of regeneration at the level of the nerve trunk has not been established.
摘要
对大鼠坐骨神经切断后通过 Y 形硅胶管再生轴突的生长情况进行了观察。当神经的远侧断端缝合到管的一个远侧分支中，而脂肪垫缝合到另一个分支中时，发现轴突明显倾向于向远侧断端再生。在其他实验中，坐骨神经腓总或胫神经分支的再生轴突可选择向腓总或胫神经生长，每条神经分别插入 Y 形管的两个远侧分支之一。未检测到近端断端向其相应远侧断端再生的明显偏好。因此，已证实远侧断端对神经具有神经营养作用，但尚未确定神经干水平再生的拓扑特异性。
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