Vradzhaliev Z H, Danev S
Vutr Boles. 1978;17(2):8-17.
The activity of GOT, GPT, APh, liver APh, gamma GTP, AAP and serum cholinesterase were determined in 80 patients with chronic liver diseases, diagnosed clinically, laparoscopically and by liver biopsy. Out of the patients with liver cirrhosis (51), those with portal cirrhosis (40) have a considerably higher activity of gamma GTP, intestinal APh than the patients with postecrotic cirrhosis (11). Cholinesterase activity is markedly lower in patients with cirrhosis and ascites than in the patients without ascites. With the histological data about the activity gamma GTP and GOT are considerably higher without activity. Examinations were carried out also upon patients with chronic aggressive hepatitis (4), chronic persisting hepatitis (9), liver cancer (12) and liver steatosis (4). The data revealed that the majority of the enzymes are with a higher sensitivity (especially gamma GTP, GOT, liver APh, cholinesterase) but with more restricted diagnostic and differential-diagnostic potentialities in view of the great dispersion of the enzyme activities with the separate liver diseases.
对80例经临床、腹腔镜及肝活检确诊的慢性肝病患者测定了谷草转氨酶（GOT）、谷丙转氨酶（GPT）、碱性磷酸酶（APh）、肝碱性磷酸酶、γ-谷氨酰转肽酶（γGTP）、α1-抗胰蛋白酶（AAP）及血清胆碱酯酶的活性。在肝硬化患者（51例）中，门脉性肝硬化患者（40例）的γGTP、肠碱性磷酸酶活性明显高于坏死后性肝硬化患者（11例）。肝硬化腹水患者的胆碱酯酶活性明显低于无腹水患者。根据组织学资料，γGTP和GOT无活性时活性明显较高。还对慢性活动性肝炎患者（4例）、慢性迁延性肝炎患者（9例）、肝癌患者（12例）及肝脂肪变性患者（4例）进行了检查。数据显示，大多数酶具有较高的敏感性（尤其是γGTP、GOT、肝碱性磷酸酶、胆碱酯酶），但鉴于不同肝病患者酶活性差异较大，其诊断和鉴别诊断潜力较为有限。
