Squier M V, Thompson J, Rajgopalan B
Department of Neuropathology, Radcliffe Infirmary, Oxford.
Neuropathol Appl Neurobiol. 1992 Dec;18(6):579-84. doi: 10.1111/j.1365-2990.1992.tb00829.x.
The neuropathological findings in a man and his dog both of whom died after acute exposure to methyl bromide are presented. The dog had cerebral oedema, most marked in the depths of cortical sulci. The man survived 30 days after the initial illness and his brain contained well-defined symmetrical lesions in the mammillary bodies and inferior colliculi. He also had a peripheral neuropathy and lymphocytic thyroiditis. The pathology in the central nervous system has features resembling Wernicke's encephalopathology; the mechanism by which methyl bromide may produce such lesions is discussed.
本文介绍了一名男子及其狗在急性接触溴甲烷后死亡的神经病理学发现。狗出现了脑水肿，在皮质沟深处最为明显。该男子在初次发病后存活了30天，其大脑在乳头体和下丘中有明确的对称性病变。他还患有周围神经病变和淋巴细胞性甲状腺炎。中枢神经系统的病理学表现类似于韦尼克脑病的病理学特征；文中讨论了溴甲烷可能产生此类病变的机制。
