Swarbrick J, Siverly J R
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
Pharm Res. 1992 Dec;9(12):1550-5. doi: 10.1023/a:1015852022343.
The influence of liquid crystalline (LC) phases on the percutaneous absorption of a model compound (ploxicromil; PXC) was studied with the use of the phase diagram for the surfactant, oil, and water comprising the vehicles. Two separate sets of vehicles, representing two different tie lines lying in the L1 + LC phase region, were prepared in which the concentration of LC was varied over the range 0 to 100% along each tie line. In vitro permeation studies of PXC from these systems were conducted using excised human skin and the flux values determined as a function of the percentage LC present in the vehicles. In virtually all cases, the flux reached a peak at 5-10% LC and then decreased significantly as the fraction of LC present increased further. The pattern of behavior observed is discussed in terms of current theories describing membrane-controlled and vehicle-controlled diffusion, none of which adequately model the results obtained.
利用包含载体的表面活性剂、油和水的相图，研究了液晶（LC）相对模型化合物（泊罗克罗米；PXC）经皮吸收的影响。制备了两组不同的载体，它们代表位于L1 + LC相区的两条不同的连接线，其中沿每条连接线，LC的浓度在0至100%的范围内变化。使用切除的人体皮肤对这些体系中的PXC进行体外渗透研究，并将通量值确定为载体中LC百分比的函数。几乎在所有情况下，通量在LC含量为5 - 10%时达到峰值，然后随着LC含量的进一步增加而显著下降。根据描述膜控和载体控扩散的当前理论对观察到的行为模式进行了讨论，但这些理论均无法充分模拟所获得的结果。
