Swarbrick J, Siverly J R
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
Pharm Res. 1992 Dec;9(12):1546-9. doi: 10.1023/a:1015899905505.
A phase diagram approach has been used to formulate topically applied vehicles containing liquid crystalline phases. The current paper describes the construction of a major portion of the polyoxyethylene(20)cetyl ether:dodecanol:water phase diagram. Known mixtures of the three components were equilibrated and centrifuged to separate the resultant conjugate phases. These were identified and analyzed quantitatively to determine phase boundaries in relevant portions of the phase diagram. Two isotropic liquid phases, several two- and three-phase regions, a solid surfactant phase, and at least three distinct liquid crystalline phases were identified. The determination of tie lines was undertaken in a two-phase region containing an aqueous isotropic micellar solution and a liquid crystalline gel. This information will be used to prepare a number of vehicles of known phase composition and concentration for a systematic evaluation of the effect of liquid crystalline phases on transdermal drug delivery.
一种相图方法已被用于配制含有液晶相的局部应用载体。本文描述了聚氧乙烯（20）十六烷基醚：十二烷醇：水相图主要部分的构建。将三种组分的已知混合物进行平衡并离心，以分离产生的共轭相。对这些共轭相进行鉴定和定量分析，以确定相图相关部分的相界。确定了两个各向同性液相、几个两相和三相区域、一个固体表面活性剂相以及至少三个不同的液晶相。在一个包含水相各向同性胶束溶液和液晶凝胶的两相区域内进行了系线的测定。这些信息将用于制备多种已知相组成和浓度的载体，以便系统评估液晶相对透皮给药的影响。
