促肾上腺皮质激素对结核菌素超敏反应和松节油所致炎症以及循环抗体水平的影响。
The effect of adrenocorticotropic hormone on inflammation due to tuberculin hypersensitivity and turpentine and on circulating antibody levels.
作者信息
OSGOOD C K, FAVOUR C B
出版信息
J Exp Med. 1951 Nov;94(5):415-30. doi: 10.1084/jem.94.5.415.
Abstract
The treatment with adrenocorticotropic hormone of guinea pigs sensitized with heat-killed tubercle bacilli caused suppression of their skin reactivity to tuberculin. Similar animals treated with saline did not show this change. Normal guinea pigs treated with adrenocorticotropic hormone showed suppression of inflammation, but not necrosis, produced by intracutaneous oil of turpentine. There was slight, but probably not significant, diminution of inflammation during saline administration. Tuberculin complement-fixing antibody titers were not altered by either adrenocorticotropic hormone or saline administration. Adrenocorticotropic hormone produced marked eosinopenia and lymphopenia in guinea pigs.
摘要
用促肾上腺皮质激素治疗经热灭活结核杆菌致敏的豚鼠，可导致其皮肤对结核菌素的反应性受到抑制。用生理盐水处理的类似动物未出现这种变化。用促肾上腺皮质激素治疗的正常豚鼠，皮内注射松节油后炎症受到抑制，但未出现坏死。注射生理盐水期间炎症有轻微减轻，但可能不显著。促肾上腺皮质激素或生理盐水给药均未改变结核菌素补体结合抗体滴度。促肾上腺皮质激素可使豚鼠出现明显的嗜酸性粒细胞减少和淋巴细胞减少。
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