万古霉素在未感染胸骨中的渗透情况。
Penetration of vancomycin in uninfected sternal bone.
作者信息
Massias L, Dubois C, de Lentdecker P, Brodaty O, Fischler M, Farinotti R
机构信息
Service de Pharmacie Clinique et des Biomatériaux, CHU Xavier Bichat-Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1992 Nov;36(11):2539-41. doi: 10.1128/AAC.36.11.2539.
Abstract
Concentrations of vancomycin in sternal bones of 10 patients undergoing cardiac surgery were studied at steady state, 48 h after starting intravenous prophylaxis. A sample of sternal bone was taken before (group I) or after (group II) cardiopulmonary bypass. The mean vancomycin concentrations in sternal bones were not significantly different between the groups and were 9.3 +/- 3.0 micrograms/g. The concentrations of vancomycin in sternal bones were always above the MICs for staphylococci, streptococci, and enterococci.
摘要
对10例接受心脏手术的患者在静脉预防性用药48小时达到稳态时胸骨中万古霉素的浓度进行了研究。在体外循环前（I组）或体外循环后（II组）采集胸骨样本。两组胸骨中万古霉素的平均浓度无显著差异，为9.3±3.0微克/克。胸骨中万古霉素的浓度始终高于葡萄球菌、链球菌和肠球菌的最低抑菌浓度。
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