Penetration of vancomycin in uninfected sternal bone.
作者信息
Massias L, Dubois C, de Lentdecker P, Brodaty O, Fischler M, Farinotti R
机构信息
Service de Pharmacie Clinique et des Biomatériaux, CHU Xavier Bichat-Claude Bernard, Paris, France.
出版信息
Antimicrob Agents Chemother. 1992 Nov;36(11):2539-41. doi: 10.1128/AAC.36.11.2539.
Abstract
Concentrations of vancomycin in sternal bones of 10 patients undergoing cardiac surgery were studied at steady state, 48 h after starting intravenous prophylaxis. A sample of sternal bone was taken before (group I) or after (group II) cardiopulmonary bypass. The mean vancomycin concentrations in sternal bones were not significantly different between the groups and were 9.3 +/- 3.0 micrograms/g. The concentrations of vancomycin in sternal bones were always above the MICs for staphylococci, streptococci, and enterococci.
摘要
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