[胍衍生物对兔脑胆碱乙酰化酶和乙酰胆碱酯酶的作用]
[Effect of guanidine dderivatives on choline acetylase and acetylcholinesterase of the rabbit brain].
作者信息
Matsumoto M, Fujiwara M, Mori A, Robin Y
出版信息
C R Seances Soc Biol Fil. 1977;171(6):1226-9.
PMID:148952
Abstract
The effects of 14 guanidino compounds on the activity of rabbit brain choline acetyltransferase (CAT) and acetylcholine esterase (ACE) have been studied, comparatively with that of pentylentetrazol. No guanidino compound examined nor pentylentetrazol had an effect on CAT activity. 4 of them showed a moderate inhibitory effect on ACE, of the same order of magnitude as that of pentylentetrazol, but significantly lower than that of the specific inhibitors eserine and mytelase.
摘要
已对14种胍基化合物对兔脑胆碱乙酰转移酶（CAT）和乙酰胆碱酯酶（ACE）活性的影响进行了研究，并与戊四氮的影响进行了比较。所检测的胍基化合物和戊四氮均对CAT活性无影响。其中4种对ACE有中等程度的抑制作用，与戊四氮的抑制作用程度相当，但明显低于特异性抑制剂毒扁豆碱和米替拉辛的抑制作用。
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