Zieliński M, Korczak-Dziuba K, Herman Z S
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):29-34.
Choline acetyltransferase (Ach-T) and acetylcholinesterase (Ach-E) activities in mice brain during the reverse action by imipramine, pheniprazine and pargyline to the syndrome elicited by intraperitoneal administration of Ro 4--1284 were investigated. A single dose of imipramine did not reverse reserpine-like syndrome whereas inhibited Ach-E activity and increased Ach-T activity at the same time. The reversal of reserpine-like syndrome by administration of pargyline, pheniprazine or chronic administration of imipramine was accompanied by no changes in Ach-E and Ach-T activities.
研究了丙咪嗪、苯乙肼和优降宁对腹腔注射Ro 4-1284所致综合征进行逆向作用时，小鼠脑中胆碱乙酰转移酶（Ach-T）和乙酰胆碱酯酶（Ach-E）的活性。单剂量丙咪嗪不能逆转利血平样综合征，却能同时抑制Ach-E活性并增加Ach-T活性。给予优降宁、苯乙肼或长期给予丙咪嗪使利血平样综合征逆转时，Ach-E和Ach-T活性未发生变化。
