一种源自CD4的肽载体在体外可阻断急性HIV-1感染，并在存在沃尔特·里德1-6期HIV阳性血清的情况下与gp120结合。
A CD4-derived peptide carrier blocks acute HIV-1 infection in vitro and binds to gp120 in the presence of Walter-Reed stage 1-6 HIV+ sera.
作者信息
Ghetie V, Wheeler T, Scott D, Uhr J W, Vitetta E S
机构信息
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235-9048.
出版信息
AIDS Res Hum Retroviruses. 1992 Nov;8(11):1945-8. doi: 10.1089/aid.1992.8.1945.
A peptide containing amino acid residues 41-84 of the CD4 molecule was synthesized and coupled through a thioether bond to human serum albumin. This conjugate bound to gp120 with an affinity that was half that of CD4 and blocked the HIV infection in vitro with an efficacy tenfold lower than that of CD4. More importantly, the CD4 peptide-human serum albumin conjugate could bind to gp120 in the presence of HIV+ sera from 18 Walter Reed stage 1-6 patients.
合成了一种包含CD4分子41 - 84位氨基酸残基的肽，并通过硫醚键与人类血清白蛋白偶联。这种偶联物与gp120结合的亲和力是CD4的一半，并且在体外阻断HIV感染的效力比CD4低10倍。更重要的是，在来自18名沃尔特·里德1 - 6期患者的HIV阳性血清存在的情况下，CD4肽 - 人类血清白蛋白偶联物仍能与gp120结合。
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