Parker J C, Smarr K L, Angelone E O, Mothersead P K, Lee B S, Walker S E, Bridges A J, Caldwell C W
Arthritis Care Res. 1992 Dec;5(4):196-201. doi: 10.1002/art.1790050403.
The purpose of this study was to use structural equation modeling techniques to examine potential interrelationships among psychological factors, immunologic activation, and disease activity in rheumatoid arthritis (RA). The subjects were 80 male patients with a diagnosis of classic or definite RA. Measures included the Beck Depression Inventory, the Arthritis Helplessness Index, and the Arthritis Impact Measurement Scales (AIMS) pain score. Joint counts and immunophenotypic analyses of peripheral blood lymphocytes also were collected. Path analysis showed that percentage of HLA-DR+ cells in the peripheral blood and helplessness were related to join count. In addition, joint count had an effect upon depression. Depression had an effect upon pain, but there was no reciprocal effect of pain upon depression. This study describes a preliminary path model of interrelationships among psychological factors, immunologic activation, and disease activity in RA.
本研究的目的是运用结构方程建模技术，检验类风湿关节炎（RA）中心理因素、免疫激活与疾病活动之间潜在的相互关系。研究对象为80名诊断为典型或确诊RA的男性患者。测量指标包括贝克抑郁量表、关节炎无助感指数以及关节炎影响测量量表（AIMS）疼痛评分。同时还收集了关节计数和外周血淋巴细胞免疫表型分析数据。路径分析表明，外周血中HLA-DR+细胞百分比和无助感与关节计数相关。此外，关节计数对抑郁有影响。抑郁对疼痛有影响，但疼痛对抑郁没有反向影响。本研究描述了RA中心理因素、免疫激活与疾病活动之间相互关系的初步路径模型。
