Burckhardt C S, Clark S R, Bennett R M
Arthritis Care Res. 1992 Dec;5(4):216-22. doi: 10.1002/art.1790050406.
Two studies were conducted to characterize the pain of fibromyalgia syndrome (FMS); to compare it to rheumatoid arthritis (RA) pain; and to examine the relationships between depression, pain extent, and pain description. Two methods of administering the McGill Pain Questionnaire (MPQ) were used. When the MPQ was administered in the standard manner, FMS pain could not be distinguished from RA pain. When participants were allowed to select as many words from an adapted MPQ as they wished, significant differences in word choice emerged. Depression and pain extent were major predictors of group differences in the evaluation of pain. However, depression scores contributed only 50% of the explanation for the differences in pain extent, with group membership contributing the other 50%. These findings suggest that the character and extent of pain in FMS are at least partially due to peripheral sensory components and not simply centrally controlled pain amplification secondary to depression.
进行了两项研究，以描述纤维肌痛综合征（FMS）的疼痛特征；将其与类风湿性关节炎（RA）的疼痛进行比较；并研究抑郁、疼痛程度和疼痛描述之间的关系。使用了两种方式来实施麦吉尔疼痛问卷（MPQ）。当以标准方式实施MPQ时，FMS疼痛无法与RA疼痛区分开来。当允许参与者从改编后的MPQ中根据自身意愿选择尽可能多的词语时，词语选择出现了显著差异。抑郁和疼痛程度是疼痛评估中组间差异的主要预测因素。然而，抑郁评分仅解释了疼痛程度差异的50%，组间差异则解释了另外50%。这些发现表明，FMS疼痛的特征和程度至少部分归因于外周感觉成分，而不仅仅是继发于抑郁的中枢性疼痛放大。
