[佐剂性关节炎大鼠肝脏中的血液钴胺素与外源性物质代谢酶]

[Blood cobalamins and xenobiotic-metabolizing enzymes in rat liver in adjuvant arthritis].

作者信息

Bartkiavichene V V, Alenene A I, Kanopkaĭte S I, Astrauskas V I, Leonavichene L K, Korsova T L, Morozova N A, Tsukerman E S, Liubarev A E, Poznanskaia A A

出版信息

Biokhimiia. 1992 Nov;57(11):1693-9.

PMID:1489828

Abstract

Changes in the total cobalamin content and spectrum of individual forms of these vitamins in blood cells and plasma as well as the activities of enzymatic systems of xenobiotic metabolism in liver microsomes of rats with experimental adjuvant arthritis (AA) have been studied. The total cobalamin content in the blood plasma of rats with AA was increased in comparison with intact animals; however, leucocytes from AA rats were deficient in methylcobalamin (MeCbl). A correlation was found between the ratios of individual cobalamin forms and their total content which was differently expressed in experimental and control animals. The development of AA was associated with marked inhibition of the cytochrome P-450-dependent monooxygenase system of the liver and glutathione transferase. The possibility of correction of these disturbances by MeCbl is discussed.

摘要

研究了实验性佐剂性关节炎（AA）大鼠血细胞和血浆中总钴胺素含量及这些维生素各形式的光谱变化，以及肝微粒体中外源物质代谢酶系统的活性。与正常动物相比，AA大鼠血浆中的总钴胺素含量增加；然而，AA大鼠的白细胞中甲基钴胺素（MeCbl）缺乏。发现各钴胺素形式的比例与其总含量之间存在相关性，这在实验动物和对照动物中有不同表现。AA的发展与肝脏中细胞色素P - 450依赖性单加氧酶系统和谷胱甘肽转移酶的显著抑制有关。讨论了用MeCbl纠正这些紊乱的可能性。