Kravchenko L V, Kuz'mina E E, Avren'eva L I, Pozdniakov A L
Vopr Med Khim. 1991 Sep-Oct;37(5):73-6.
Activity of enzymes involved in metabolism of xenobiotics was not altered in liver tissue of rats kept on a ration enriched with selenium at a dose of 2.5 mg/kg. Both organic form of selenium (yeast meal, selenomethionine) and inorganic derivatives (sodium selenite) at a dose of 5 mg/kg of ration caused distinct activation of epoxide hydrolase, UDP-glucuronosyl transferase and glutathione transferase within 6 weeks after the experiment beginning, while content of cytochrome P-450, glutathione-SH and glutathione peroxidase activity were not significantly altered. Within 9 weeks the enzymatic activity remained at the higher rate only in rats kept on the ration with sodium selenite. Relationship between toxic effects of selenium high doses and alterations in activity of enzymes involved in metabolism of xenobiotics is discussed.
以2.5毫克/千克的剂量喂食富含硒的日粮的大鼠肝脏组织中，参与外源性物质代谢的酶的活性未发生改变。实验开始6周内，以5毫克/千克日粮的剂量喂食有机形式的硒（酵母粉、硒代蛋氨酸）和无机衍生物（亚硒酸钠）均导致环氧化物水解酶、UDP-葡萄糖醛酸基转移酶和谷胱甘肽转移酶明显激活，而细胞色素P-450的含量、谷胱甘肽-SH和谷胱甘肽过氧化物酶的活性未发生显著改变。9周内，仅在喂食含亚硒酸钠日粮的大鼠中，酶活性维持在较高水平。讨论了高剂量硒的毒性作用与参与外源性物质代谢的酶活性改变之间的关系。
