Schreiber M, Kantimm D, Kirchhoff D, Heimann G, Bhargava A S
Research Laboratories, Schering AG, Experimental Toxicology, Berlin.
Eur J Clin Chem Clin Biochem. 1992 Nov;30(11):775-8. doi: 10.1515/cclm.1992.30.11.775.
The concentrations of immunoglobulins IgG, IgM and IgA and their age dependence were determined in the serum of normal, untreated beagle dogs by a newly developed sandwich enzyme-linked-immuno-sorbent-assay (ELISA). A clear age-dependent increase between approximately 0.8 and 1.6 years of age was observed for the immunoglobulin IgA, whereas IgG and IgM showed only a slight tendency to an age-dependent increase. For immunotoxicological characterization of various compounds especially in long term studies, this IgA age-dependence has to be considered in the planning and interpretation of studies with beagle dogs.
采用新开发的夹心酶联免疫吸附测定法（ELISA），测定了正常、未经治疗的比格犬血清中免疫球蛋白IgG、IgM和IgA的浓度及其与年龄的关系。观察到免疫球蛋白IgA在约0.8至1.6岁之间有明显的年龄依赖性增加，而IgG和IgM仅显示出轻微的年龄依赖性增加趋势。对于各种化合物的免疫毒理学特征描述，尤其是在长期研究中，在比格犬研究的规划和解释中必须考虑这种IgA的年龄依赖性。
