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慢性抗抑郁药治疗对大鼠纹状体中与多巴胺相关的[3H]SCH 23390和[3H]螺哌隆结合的影响。

Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]spiperone binding in the rat striatum.

作者信息

Paetsch P R, Greenshaw A J

机构信息

Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Canada.

出版信息

Cell Mol Neurobiol. 1992 Dec;12(6):597-606. doi: 10.1007/BF00711239.

DOI:10.1007/BF00711239
PMID:1490276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11567202/
Abstract
  1. The effects of chronic administration of antidepressants on dopamine-related [3H]SCH 23390 and [3H]spiperone binding to rat striatal membranes were assessed. 2. The monoamine oxidase inhibitors phenelzine (5 or 10 mg kg-1/day) and tranylcypromine (1 mg kg-1/day) and the tricyclic desipramine (10 mg kg-1/day) were administered for 28 days by constant subcutaneous infusion using Alzet (2ML4) osmotic minipumps. 3. These treatments did not alter Kd estimates for either [3H]SCH 23390 or [3H]spiperone binding sites. The monoamine oxidase inhibitors induced a decrease in the Bmax values for both [3H]SCH 23990 and [3H]spiperone binding sites. Desipramine induced a decrease in the Bmax value for [3H]SCH 23390 binding but had no effect on the Bmax value for [3H]spiperone binding.
摘要
  1. 评估了长期给予抗抑郁药对多巴胺相关的[3H]SCH 23390和[3H]螺哌隆与大鼠纹状体膜结合的影响。2. 使用Alzet（2ML4）渗透微型泵通过持续皮下输注给予单胺氧化酶抑制剂苯乙肼（5或10毫克/千克/天）和反苯环丙胺（1毫克/千克/天）以及三环类药物地昔帕明（10毫克/千克/天），持续28天。3. 这些处理并未改变[3H]SCH 23390或[3H]螺哌隆结合位点的解离常数（Kd）估计值。单胺氧化酶抑制剂导致[3H]SCH 23990和[3H]螺哌隆结合位点的最大结合容量（Bmax）值降低。地昔帕明导致[3H]SCH 23390结合的Bmax值降低，但对[3H]螺哌隆结合的Bmax值没有影响。

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本文引用的文献

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Effects of chronic antidepressant treatment on nigrostriatal and mesolimbic dopamine autoreceptors in the rat.
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