Oreland L, Wiberg A, Asberg M, Träskman L, Sjöstrand L, Thorén P, Bertilsson L, Tybring G
Psychiatry Res. 1981 Feb;4(1):21-9. doi: 10.1016/0165-1781(81)90004-4.
Platelet monoamine oxidase (MAO) activity and cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5HIAA), homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenylglycol (HMPG) were simultaneously measured in 20 currently depressed patients, 11 recovered depressed patients, 15 nondepressed suicide attempters, and 42 healthy control subjects. Both 5HIAA and HVA were positively and significantly correlated to platelet MAO activity in the healthy subjects, but not in any of the patient groups. Suicide attempters had significantly lower CSF 5HIAA than nonsuicidal patients.
对20名当前患有抑郁症的患者、11名已康复的抑郁症患者、15名非抑郁症自杀未遂者和42名健康对照者同时测定了血小板单胺氧化酶（MAO）活性以及脑脊液（CSF）中5-羟吲哚乙酸（5HIAA）、高香草酸（HVA）和4-羟基-3-甲氧基苯乙二醇（HMPG）的浓度。在健康受试者中，5HIAA和HVA均与血小板MAO活性呈显著正相关，但在任何患者组中均无此相关性。自杀未遂者脑脊液中的5HIAA显著低于非自杀患者。
