高密度脂蛋白胆固醇/总胆固醇比值与载脂蛋白A1/载脂蛋白B之间的观察关系。

Observed relationship between ratios HDL-cholesterol/total cholesterol and apolipoprotein A1/apolipoprotein B.

作者信息

Kuyl J M, Mendelsohn D

机构信息

Departments of Chemical Pathology, University of the Orange Free State, Witwatersrand, South Africa.

出版信息

Clin Biochem. 1992 Oct;25(5):313-6. doi: 10.1016/0009-9120(92)80004-z.

DOI:10.1016/0009-9120(92)80004-z

PMID:1490290

Abstract

Epidemiological evidence suggests that the ratio HDL-cholesterol (HDL-C)/total cholesterol (TC) or apolipoprotein A1 (apo A1)/apolipoprotein B (apo B) are good indicators of coronary heart disease risk. In investigating the distribution of these ratios in the typical population served by our routine laboratory, we analysed the lipid results of 541 serum samples submitted over a 2-month period for TC, HDL-C, apo A1, and apo B. Good correlation was observed between HDL-C and apo A1 (r = 0.664), and between TC and apo B (r = 0.674). Surprisingly, the correlation between the ratios HDL-C/TC (range: 0.05-0.40) and apo A1/apo B (range: 0.27-3.71) was even higher (r = 0.822). Similar significant correlations were observed in 31 heterozygous and 20 homozygous familial hypercholesterolemic subjects, viz. the correlations between HDL-C/TC (ranges: 0.04-0.24 and 0.02-0.12, respectively) and apo A1/apo B (ranges: 0.47-1.84 and 0.15-1.12, respectively) were r = 0.951 and r = 0.972, respectively.

摘要

流行病学证据表明，高密度脂蛋白胆固醇（HDL-C）/总胆固醇（TC）的比值或载脂蛋白A1（apo A1）/载脂蛋白B（apo B）的比值是冠心病风险的良好指标。在调查我们常规实验室所服务的典型人群中这些比值的分布情况时，我们分析了在两个月期间提交的541份血清样本中TC、HDL-C、apo A1和apo B的血脂检测结果。观察到HDL-C与apo A1之间存在良好的相关性（r = 0.664），以及TC与apo B之间存在良好的相关性（r = 0.674）。令人惊讶的是，HDL-C/TC比值（范围：0.05 - 0.40）与apo A1/apo B比值（范围：0.27 - 3.71）之间的相关性甚至更高（r = 0.822）。在31名杂合子和20名纯合子家族性高胆固醇血症患者中也观察到了类似的显著相关性，即HDL-C/TC比值（范围分别为：0.04 - 0.24和0.02 - 0.12）与apo A1/apo B比值（范围分别为：0.47 - 1.84和0.15 - 1.12）之间的相关性分别为r = 0.951和r = 0.972。